1-deoxy-D-xylulose-5-phosphate reductoisomerase EC#: 1.1.1.267; ChemWhat Code: 1373358
| Product Name | 1-deoxy-D-xylulose-5-phosphate reductoisomerase |
| Example Structure |  |
| Synonyms | 1-deoxy-D-xylulose 5-phosphate isomeroreductase, 1-deoxy-D-xylulose 5-phosphate reductoisomerase, 1-deoxy-D-xylulose-5-phosphate, 1-deoxy-D-xylulose-5-phosphate reductoisomerase, 1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase, 2C-methyl-D-erythritol 4-phosphate synthase, 2C-methyl-D-erythritol-4-phosphate synthase, deoxyxylulose 5-phosphate reductoisomerase, deoxyxylulosephosphate reductoisomerase, DOXP reductoisomerase, DOXP-reductoisomerase, DXP reductoisomerase, DXP-reductoisomerase, DXR, DXR1, IspC, MEP synthase, meps, methylerythritol phosphate synthase, PdDXR, Rv2870c |
| EC Number | 1.1.1.267 |
| CAS Registry Number | 210756-42-6 |
| Comments | The enzyme requires Mn2+, Co2+ or Mg2+ for activity, with the first being most effective. The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis. The mechanism has been shown to be a retroaldol/aldol reaction [2]. |
| Cofactor | Mg2+ or cobalt cation or Mn2+ |
| History | |
| Reactions | 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + Nadph. |
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