1,2-dehydroreticuline synthase EC#: 1.14.19.54; ChemWhat Code: 1375819
| Product Name | 1,2-dehydroreticuline synthase |
| Example Structure |  |
| Synonyms | CYP82Y2, DRS, STORR |
| EC Number | 1.14.19.54 |
| CAS Registry Number | |
| Comments | A P450 (heme-thiolate) cytochrome. The enzyme from Papaver rhoeas (field poppy) is specific for (S)-reticuline and does not act on the (R)-form. The enzyme from Papaver somniferum (opium poppy), which is involved in the biosynthesis of morphine and related alkaloids, forms a fusion protein with EC 1.5.1.27, 1,2-dehydroreticulinium reductase (NADPH), which catalyses the reduction of 1,2-dehydroreticuline to (R)-reticuline, thus forming an epimerase system that converts (S)-reticuline to (R)-reticuline. |
| Cofactor | heme-thiolate |
| History | |
| Reactions |
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