16S rRNA (adenine1408-N1)-methyltransferase EC#: 2.1.1.180; ChemWhat Code: 1376394
| Product Name | 16S rRNA (adenine1408-N1)-methyltransferase |
| Example Structure |  |
| Synonyms | 16S rRNA (m1A1408) methyltransferase, 16S rRNA m1A1408 methyltransferase, 16S rRNA:m(1)A1408 methyltransferase, A1408 16S rRNA methyltransferase, KAM, KamB, kanamycin-apramycin resistance methylase, m1A1408, NpmA, plasmid-mediated 16S rRNA methyltransferase A, ShKam |
| EC Number | 2.1.1.180 |
| CAS Registry Number | |
| Comments | The enzyme provides a panaminoglycoside-resistant nature through interference with the binding of aminoglycosides toward the A site of 16S rRNA through N1-methylation at position adenine1408 [4]. |
| Cofactor | |
| History | |
| Reactions | S-adenosyl-L-methionine + adenine(1408) in 16S rRNA = S-adenosyl-L- homocysteine + N(1)-methyladenine(1408) in 16S rRNA. |
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