16S rRNA (guanine1405-N7)-methyltransferase EC#: 2.1.1.179; ChemWhat Code: 1376392
| Product Name | 16S rRNA (guanine1405-N7)-methyltransferase |
| Example Structure |  |
| Synonyms | 16S rRNA (m7G1405) methyltransferase, 16S rRNA methyltransferase, 16S rRNA N7 G1405 methyltransferase, 16S-RMTase, ArmA, FmrO, G1405 methyltransferase ArmA, GrmA, GrmB, Kmr, Krm, M7G1405 MTase, methyltransferase RmtC, methyltransferase Sgm, N7-G1405 16S-RMTase, NbrB, RmtA, RmtB, RmtC, RmtD, RmtD2, RmtF, RmtG, sgm, Sgm methyltransferase, Sgm MTase, sisomicin-gentamicin methylase, sisomicin-gentamicin methyltransferase, sisomicin-gentamicin resistance methylase, Smr1 |
| EC Number | 2.1.1.179 |
| CAS Registry Number | |
| Comments | The enzyme from the antibiotic-producing bacterium Micromonospora zionensisspecifically methylates guanine1405 at N7 in 16S rRNA, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins [2]. |
| Cofactor | |
| History | |
| Reactions | S-adenosyl-L-methionine + guanine(1405) in 16S rRNA = S-adenosyl-L- homocysteine + N(7)-methylguanine(1405) in 16S rRNA. |
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