2′-5′ oligoadenylate synthase EC#: 2.7.7.84; ChemWhat Code: 1378891
| Product Name | 2′-5′ oligoadenylate synthase |
| Example Structure |  |
| Synonyms | (2-5)A synthetase, 2′,5′-An synthetase, 2′,5′-OASE, 2′,5′-oligoadenylate synthetase, 2′,5’oligoadenylate synthetase, 2′,5’oligoadenylate synthetase 1b, 2′-5′ oligoadenylate synthetase, 2′-5′-oligoadenylate synthetase, 2′-5’OAS, 2’5′ oligoadenylate synthetase, 2-5A synthetase, ATP(2′,5′)-oligo(A) adenylyltransferase, OAS, OAS1, OAS1A, OAS2, OAS3 |
| EC Number | 2.7.7.84 |
| CAS Registry Number | |
| Comments | The enzyme is activated by binding to double-stranded RNA. The resulting product binds to and activates RNase L, which subsequently degrades the RNA. Oligoadenylates of chain lengths 2, 4 and 5 are also produced. The dimer does not have any known biological activity [2]. |
| Cofactor | |
| History | |
| Reactions | 3 Atp = pppA2’p5’A2’p5’A + 2 diphosphate. |
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