2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase EC#: 2.7.6.3; ChemWhat Code: 1378740

Product Name 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
Example Structure Example Structure of 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase EC#: 2.7.6.3
Synonyms
EC Number 2.7.6.3
CAS Registry Number 37278-23-2
Comments Binds 2 Mg2+?ions that are essential for activity [4]. The enzyme participates in the pathways for folate (in bacteria, plants and fungi) and methanopterin (in archaea). The enzyme exists in varying types of multifunctional proteins in different organisms. The enzyme from the bacterium?Streptococcus pneumoniae?also harbours the activity of EC?4.1.2.25, dihydroneopterin aldolase [4], the enzyme from the plant?Arabidopsis thaliana?harbours the activity of EC?2.5.1.15, dihydropteroate synthase [7], while the enzyme from yeast?Saccharomyces cerevisiae?is trifunctional with both of the two above mentioned activities [6].
Cofactor Mg2+
History
Reactions Atp + 6-hydroxymethyl-7,8-dihydropterin = amp + 6-hydroxymethyl-7,8- dihydropterin diphosphate.

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