naphthoic acid/coenzyme A ligase, naphthoyl CoA ligase, NcsB2
EC Number
6.2.1.43
CAS Registry Number
Comments
The enzyme from the bacterium?Streptomyces carzinostaticus?is involved in the attachment of the 2-hydroxy-7-methoxy-5-methyl-1-naphthoate moiety of the antibiotic neocarzinostatin.?In vitro?the enzyme also catalyses the activation of other 1-naphthoic acid analogues, e.g. 2-hydroxy-5-methyl-1-naphthoate or 2,7-dihydroxy-5-methyl-1-naphthoate.
Cofactor
History
Reactions
Atp + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + CoA = amp + diphosphate + 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA.
