2-hydroxymethylglutarate dehydrogenase EC#: 1.1.1.291; ChemWhat Code: 1373394
| Product Name | 2-hydroxymethylglutarate dehydrogenase |
| Example Structure |  |
| Synonyms | HgD |
| EC Number | 1.1.1.291 |
| CAS Registry Number | |
| Comments | NADP+ cannot replace NAD+. Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. Other enzymes involved in this pathway are EC 1.17.1.5 (nicotinate dehydrogenase), EC 1.3.7.1 (6-hydroxynicotinate reductase), EC 3.5.2.18 (enamidase), EC 5.4.99.4 (2-methyleneglutarate mutase), EC 5.3.3.6 (methylitaconate ¦¤-isomerase), EC 4.2.1.85 (dimethylmaleate hydratase) and EC 4.1.3.32 (2,3-dimethylmalate lyase). |
| Cofactor | |
| History | |
| Reactions | (S)-2-hydroxymethylglutarate + NAD(+) = 2-formylglutarate + Nadh. |
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