(R)-hydroxypropyl-coenzyme M dehydrogenase, (R)-hydroxypropylthioethanesulfonate dehydrogenase, 2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase, 2-(R)-hydroxypropyl-coenzyme M dehydrogenase, R-HPCDH, xecD
EC Number
1.1.1.268
CAS Registry Number
Comments
The enzyme is highly specific for (R)-2-hydroxyalkyl thioethers of CoM, in contrast to EC 1.1.1.269, 2-(S)-hydroxypropyl-CoM dehydrogenase, which is highly specific for the (S)-enantiomer. This enzyme forms component III of a four-component enzyme system {comprising EC 4.4.1.23 (2-hydroxypropyl-CoM lyase; component I), EC 1.8.1.5 [2-oxopropyl-CoM reductase (carboxylating); component II], EC 1.1.1.268 [2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC 1.1.1.269 [2-(S)-hydroxypropyl-CoM dehydrogenase; component IV]} that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2.
