23S rRNA (cytidine1920-2′-O)-methyltransferase EC#: 2.1.1.226; ChemWhat Code: 1376470

Product Name 23S rRNA (cytidine1920-2′-O)-methyltransferase
Example Structure Example Structure of 23S rRNA (cytidine1920-2'-O)-methyltransferase EC#: 2.1.1.226
Synonyms 2′-O-methyltransferase, TlyA, TlyAI, TlyAII
EC Number 2.1.1.226
CAS Registry Number
Comments The bifunctional enzyme from Mycobacterium tuberculosis 2′-O-methylates cytidine1920 in helix 69 of 23S rRNA and cytidine1409 in helix 44 of 16S rRNA (cf. EC 2.1.1.227, 16S rRNA (cytidine1409-2′-O)-methyltransferase). These methylations result in increased susceptibility to the antibiotics capreomycin and viomycin.
Cofactor
History
Reactions S-adenosyl-L-methionine + cytidine(1920) in 23S rRNA = S-adenosyl-L- homocysteine + 2′-O-methylcytidine(1920) in 23S rRNA.

Buy Reagent

No reagent supplier? Send quick inquiry to ChemWhat
Want to be listed here as a reagent supplier? (Paid service) Click here to contact ChemWhat

Approved Manufacturers

Want to be listed as an approved manufacturer (Requires approvement)? Please download and fill out this form and send back to approved-manufacturers@chemwhat.com

Contact Us for Other Help

Contact us for other information or services Click here to contact ChemWhat