23S rRNA (uridine2479-2′-O)-methyltransferase EC#: 2.1.1.208; ChemWhat Code: 1376442
| Product Name | 23S rRNA (uridine2479-2′-O)-methyltransferase |
| Example Structure |  |
| Synonyms | AviRb |
| EC Number | 2.1.1.208 |
| CAS Registry Number | |
| Comments | Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis. To protect itself from the antibiotic, Streptomyces viridochromogenes utilizes two methyltransferases, 23S rRNA (uridine2479-2′-O)-methyltransferase and EC 2.1.1.209 [23S rRNA (guanine2535-N1)-methyltransferase], whose actions confer avilamycin resistance to the RNA. |
| Cofactor | |
| History | |
| Reactions | S-adenosyl-L-methionine + uridine(2479) in 23S rRNA = S-adenosyl-L- homocysteine + 2′-O-methyluridine(2479) in 23S rRNA. |
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