| Synonyms |
3-hexulose phosphate synthase, 3-hexulose-6-phosphate formaldehyde lyase, 3-hexulose-6-phosphate synthase, 3-hexulose-phosphate synthase, 3-hexulosephosphate synthase, D-arabino-3-hexulose 6-phosphate formaldehyde lyase, D-arabino-3-hexulose 6-phosphate formaldehyde-lyase, Fae-Hps, hexose phosphate synthase, hexulose-6-phosphate synthase, HPS, HPS-aldolase, HPS-PHI, HPS/PHI |
| Comments |
Requires Mg2+?or Mn2+?for maximal activity [1]. The enzyme is specific for formaldehyde and D-ribulose 5-phosphate as substrates. Ribose 5-phosphate, xylulose 5-phosphate, allulose 6-phosphate and fructose 6-phosphate cannot act as substrate. This enzyme, along with EC?5.3.1.27, 6-phospho-3-hexuloisomerase, plays a key role in the ribulose-monophosphate cycle of formaldehyde fixation, which is present in many microorganisms that are capable of utilizing C1-compounds [1]. The hyperthermophilic and anaerobic archaeon?Pyrococcus horikoshii?OT3 constitutively produces a bifunctional enzyme that sequentially catalyses the reactions of this enzyme and EC?5.3.1.27, 6-phospho-3-hexuloisomerase [6]. This enzyme is a member of the orotidine 5′-monophosphate decarboxylase (OMPDC) suprafamily [5]. |
