4-MHA activating enzyme, 4-MHA pentapeptide lactone synthase AcmA, 4-MHA-activating enzyme, AcmA, ACMS I, ACMSI, actinomycin synthase I, actinomycin synthetase I, sibE
EC Number
2.7.7.97
CAS Registry Number
Comments
The enzyme, characterized from the bacteria?Streptomyces anulatus?and?Streptosporangium sibiricum, activates 3-hydroxy-4-methylanthranilate, a precursor of actinomycin antibiotics and the antitumor antibiotic sibiromycin, to an adenylate form, so it can be loaded onto a dedicated aryl-carrier protein.
Cofactor
History
Reactions
Atp + 3-hydroxy-4-methylanthranilate = diphosphate + 3-hydroxy-4- methylanthranilyl-adenylate.
