3beta-hydroxysteroid 3-dehydrogenase EC#: 1.1.1.270; ChemWhat Code: 1373363
| Product Name | 3beta-hydroxysteroid 3-dehydrogenase |
| Example Structure |  |
| Synonyms | 17beta-hydroxysteroid dehydrogenase type 7, 3-keto reducing enzyme, 3-keto reductase, 3-keto-reductase, 3-ketoreductase, 3-ketosteroid reductase, 3-KSR, 3-oxo steroid reductase, 3-oxosteroid reductase, 3beta-HSD, 3beta-HSD1, 3beta-HSD2, 3beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase type 1, 3beta-hydroxysteroid dehydrogenase/Delta 5->4-isomerase type 1, 3beta-hydroxysteroid dehydrogenase/Delta 5->4-isomerase type 2, 3beta-hydroxysteroid dehydrogenase/isomerase, AKR1C1, AKR1C2, AKR1Cs, aldo-keto reductase 1C2, Erg27, Erg27p, Hsd17, HSD17B7, reductase, 3-oxo steroid, reductive 3beta-HSD, SDR11E1, SDR11E2, steroid-3-ketoreductase, sterol 3-ketoreductase, sterone-reducing enzyme, type 3 3alpha-hydroxysteroid dehydrogenase |
| EC Number | 1.1.1.270 |
| CAS Registry Number | 42616-29-5 |
| Comments | The enzyme acts on multiple 3¦Â-hydroxysteroids. Participates in the biosynthesis of zemosterol and cholesterol, where it catalyses the reaction in the opposite direction to that shown. The mammalian enzyme is bifunctional and also catalyses EC 1.1.1.62, 17¦Â-estradiol 17-dehydrogenase [4]. |
| Cofactor | |
| History | |
| Reactions | A 3-beta-hydroxysteroid + NADP(+) = a 3-oxosteroid + nadph. |
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