5-(carboxyamino)imidazole ribonucleotide synthase EC#: 6.3.4.18; ChemWhat Code: 1383842

Product Name 5-(carboxyamino)imidazole ribonucleotide synthase
Example Structure Example Structure of 5-(carboxyamino)imidazole ribonucleotide synthase EC#: 6.3.4.18
Synonyms More, N5-CAIR synthetase, N5-carboxyaminoimidazole ribonucleotide synthetase, N5-carboxylaminoimidazole ribonucleotide synthetase, N5CAIR synthetase, PurK
EC Number 6.3.4.18
CAS Registry Number
Comments In?Escherichia coli, this enzyme, along with EC?5.4.99.18, 5-(carboxyamino)imidazole ribonucleotide mutase, is required to carry out the single reaction catalysed by EC?4.1.1.21, phosphoribosylaminoimidazole carboxylase, in vertebrates. Belongs to the ATP grasp protein superfamily [3]. Carboxyphosphate is the putative acyl phosphate intermediate. Involved in the late stages of purine biosynthesis.
Cofactor
History
Reactions Atp + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO(3)(-) = adp + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.

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