9,12-octadecadienoate 8-hydroperoxide 8R-isomerase EC#: 5.4.4.5; ChemWhat Code: 1383363

Product Name 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase
Example Structure Example Structure of 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase EC#: 5.4.4.5
Synonyms 5,8-LDS, 5,8-linoleate diol synthase, 5,8-linoleate diol synthases, PpoA
EC Number 5.4.4.5
CAS Registry Number
Comments The enzyme contains heme [3]. The bifunctional enzyme from?Aspergillus nidulans?uses different heme domains to catalyse two separate reactions. Linoleic acid is oxidized within the N-terminal heme peroxidase domain to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate (cf. EC?1.13.11.60, linoleate 8R-lipoxygenase), which is subsequently isomerized to (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate within the C-terminal P450 heme thiolate domain [3].
Cofactor heme
History
Reactions (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (5S,8R,9Z,12Z)-5,8- dihydroxyoctadeca-9,12-dienoate.

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