ABC-type glutathione-S-conjugate transporter EC#: 7.6.2.3; ChemWhat Code: 1383982

Product Name ABC-type glutathione-S-conjugate transporter
Example Structure Example Structure of ABC-type glutathione-S-conjugate transporter EC#: 7.6.2.3
Synonyms ABCC1, ABCC2, ABCC3, ABCC4, Abcc5, ABCG2, ATP-dependent efflux pump-multidrug resistance protein 1, ATP-driven GSH transporter, BCRP, bile pigment transporter-1, Bpt1p, breast cancer resistance protein, cadmium factor protein, canalicular MRP, canalicular multispecific organic anion transporter, cMOAT, cMRP, GEX1, GEX2, glutathione S-conjugate pump, glutathione S-conjugate transporter, glutathione-conjugate transporter, glutathione-S-conjugate-translocating ATPase, GSH transporter, Hgt1p, high affinity glutathione transporter, Mpr6, Mpr7, Mpr8, MRP, MRP 1, MRP transporter, MRP-1, MRP1, MRP2, MRP3, MRP4, MRP5, MRP6, multidrug resistance associated protein 2, multidrug resistance associated protein-1, multidrug resistance protein, multidrug resistance protein 1, multidrug resistance protein 2, multidrug resistance protein transporter, multidrug resistance-associated protein, multidrug resistance-associated protein 1, multidrug resistance-associated protein 2, multidrug-resistance protein 1, Oatp1, Oatp2, organic anion transporting polypeptide, P-glycoprotein, P-glycoprotein-1, P-gp, Pgh-1, PGP-1, RLIP76, vacuolar glutathione S-conjugate transporter, YBT1, Ycf1, Ycf1p, yeast cadmium factor-1
EC Number 7.6.2.3
CAS Registry Number
Comments A eukaryotic ATP-binding cassette (ABC) type transporter that mediates the transport of glutathione-S-conjugates. The mammalian enzyme, which also transports some glucuronides, exports the substrates out of the cell, while plant and fungal transporters export them into the vacuole. Over-expression confers resistance to anticancer drugs by their efficient exportation in glutathione-S-conjugate form.
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