ATP-dependent lipid A-core flippase, EcMsbA, lipid A export ATP-binding/permease protein, lipid A export ATP-binding/permease protein MsbA, Lipid A transporter, lipid flippase, LPS flippase, More, MsbA, MsbA protein, MsbA2, pA4997, STM0984, StMsbA
EC Number
7.5.2.6
CAS Registry Number
Comments
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, best characterized from the bacterium Escherichia coli, is located in the inner membrane and mediates the movement of lipid A attached to the core oligosaccharide from the cytoplasm to the periplasmic side of the inner membrane, an important step in the lipopolysaccharide biosynthetic pathway. Not to be confused with EC 7.5.2.5, ABC-type lipopolysaccharide transporter (LptB), which is implicated in the translocation of LPS from the inner membrane to the outer membrane and acts later in the process.
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, best characterized from the bacterium Escherichia coli, is located in the inner membrane and mediates the movement of lipid A attached to the core oligosaccharide from the cytoplasm to the periplasmic side of the inner membrane, an important step in the lipopolysaccharide biosynthetic pathway. Not to be confused with EC 7.5.2.5, which is implicated in the translocation of LPS from the inner membrane to the outer membrane and acts later in the process.
