aerobactin synthase EC#: 6.3.2.39; ChemWhat Code: 1383779
| Product Name | aerobactin synthase |
| Example Structure |  |
| Synonyms | aerC, iuacC, iucC |
| EC Number | 6.3.2.39 |
| CAS Registry Number | |
| Comments | Requires Mg2+. The enzyme is involved in the biosynthesis of aerobactin, a dihydroxamate siderophore. It belongs to a class of siderophore synthases known as type C nonribosomal peptide synthase-independent synthases (NIS). Type C enzymes are responsible for the formation of amide or ester bonds between a variety of substrates and a prochiral carboxyl group of a citrate molecule that is already linked to a different moiety at its other prochiral carboxyl group. The enzyme is believed to form an adenylate intermediate prior to ligation. |
| Cofactor | Mg2+ |
| History | |
| Reactions | 2 Atp + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)- hydroxy-L-lysine + H(2)O = 2 Adp + 2 phosphate + aerobactin. |
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