Anti-Vitamin B9 (Vitamin B9, VB9, Folic Acid, CAS#: 59-30-3) antibody

Anti-Vitamin B9 (Vitamin B9, VB9, Folic Acid, CAS#: 59-30-3) antibody; ChemWhat Code: 1393871

Antigen	Description	Properties
Safety Information	Images	Other Info

Antigen

Name	Vitamin B9
Synonyms	5 Methyl THFA; 5 Methyltetrahydrofolate; Folate; Tetrahydrofolate; Tetrahydrofolic acid; THFA; Folic Acid; 59-30-3

Description

Name	Anti-Vitamin B9 antibody
	Monoclonal Folic Acid antibody, Anti-Folic Acid antibody, Folate antibody, Vitamin M antibody, Vitamin B9 antibody, Vitamin Bc antibody, Folacin antibody, Pteroyl-L-glutamic acid antibody, Pteroyl-L-glutamate antibody
Host	Mouse; Goat; Rabbit
Antibody Product Type	Primary
Conjugate	Unconjugated; Biotin; APC; Alkaline Phosphatase (AP); FITC; HRP; PE
Specifity	Recognizes free folic acid, otherwise known as Vitamin B9, a water-soluble vitamin found naturally in food. Folic acid is essential for production and maintenance of new cells particularly during pregnancy and infancy. Folate (the anion form of folic acid) functions in the synthesis of DNA bases, and folate deficiency limits cell division leading to megaloblastic anemia. Folic acid is particularly important just before and just after conception, to help protect against neural tube defects such as spina bifida.
Application	ELISA; Immunohistochemistry (IHC); Western Blotting (WB); Immunofluorescence (fixed cells) (IF/ICC); Immunoprecipitation (IP); Cell-ELISA (cELISA); Immunoassay (IA); Immunocytochemistry (ICC)

Properties

Form	Liquid/Lyophilized
Handling	The antibody solution should be gently mixed before use.
Storage Condition	Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for a year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Clonality	Monoclonal/Polyclonal
Isotype	IgG

Safety Information

RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Images

Monoclonal Anti-Folic Acid antibody produced in mouse

Other Info

About the antigen

Folic acid and Folate (the anion form) are forms of a water-soluble B vitamin. These occur naturally in food and can also be taken as supplements. The biologically active form of folic acid is tetrahydrofolic acid (THFA), which is derived by the 2-step reduction of folate involving dihydrofolate reductase. THFA plays a key role in the transfer of 1-carbon units (such as methyl, methylene, and formyl groups) to the essential substrates involved in the synthesis of DNA, RNA, and proteins. More specifically, THFA is involved with the enzymatic reactions necessary to synthesis of purines, thymidine, and amino acids. Manifestations of folate deficiency thereafter, not surprisingly, would involve impairment of cell division, accumulation of possibly toxic metabolites such as homocysteine, and impairment of methylation reactions involved in the regulation of gene expression, thus increasing neoplastic risks. Folate is necessary for the production and maintenance of new cells. This is especially important during periods of rapid cell division and growth such as infancy and pregnancy when a deficiency can result in neural tube defects. In folate deficiency the bone marrow is affected as it is a site of rapid cell turnover. Large red blood cells called megaloblasts are produced, resulting in megaloblastic anemia.

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