arsenite methyltransferase EC#: 2.1.1.137; ChemWhat Code: 1376331

Product Name arsenite methyltransferase
Example Structure Example Structure of arsenite methyltransferase EC#: 2.1.1.137
Synonyms AdoMet:arsenic(III) methyltransferase, arsenic (+3 oxidation state) methyltransferase, arsenic (+3 oxidation state)-methyltransferase, arsenic (+3) methyltransferase, arsenic (III) methyltransferase, arsenic (III) S-adenosylmethionine methyltransferase, arsenic methyltransferase Cyt19, arsenic(III) methyltransferase, arsenite (+3 oxidation state) methyltransferase, arsenite methyltransferase, arsenite S-adenosylmethionine methyltransferase, ArsM, ArsM protein, ArsM7B, As(III) methyltransferase, As(III) S-adenosylmethionine methyltransferase, As(III) SAM methyltransferase, AS3MT, AsIII S-adenosylmethionine methyltransferase, Cyr19, Cyt19, EC 2.1.1.138, hAS3MT, S-adenosyl-L-methionine:arsenic(III) methyltransferase, S-adenosylmethionine dependent arsenic methyltransferase, [As(III)] methyltransferase
EC Number 2.1.1.137
CAS Registry Number
Comments An enzyme of the biotransformation pathway that forms dimethylarsinate from inorganic arsenite and arsenate. It methylates arsenite to form methylarsonate, Me-AsO3H2, which is reduced by EC 1.20.4.2, methylarsonate reductase, to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate for this enzyme (EC 2.1.1.137), which converts it into the much less toxic compound dimethylarsinate (cacodylate), Me2As(O)-OH.
Cofactor
History
Reactions (1) S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate. (2) S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate.

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