| Synonyms |
aspartate tRNA synthetase, Aspartic acid translase, Aspartyl ribonucleic synthetase, aspartyl tRNA synthetase, aspartyl-transfer ribonucleate synthetase, Aspartyl-transfer ribonucleic acid synthetase, Aspartyl-transfer RNA synthetase, Aspartyl-tRNA synthetase, AspRS, EC 6.1.1.12, More, ND-AspRS, non-discriminating aspartyl-tRNA synthetase, nondicriminating AspRS, nondiscriminating aspartyl-tRNA synthetase, nondiscriminating AspRS, Synthetase, aspartyl-transfer ribonucleate |
| Comments |
When this enzyme acts on tRNAAsp, it catalyses the same reaction as EC?6.1.1.12, aspartate¡ªtRNA ligase. It has, however, diminished discrimination, so that it can also form aspartyl-tRNAAsn. This relaxation of specificity has been found to result from the absence of a loop in the tRNA that specifically recognizes the third position of the anticodon [1]. This accounts for the ability of this enzyme in, for example,?Thermus thermophilus, to recognize both tRNAAsp?(GUC anticodon) and tRNAAsn?(GUU anticodon). The aspartyl-tRNAAsn?is not used in protein synthesis until it is converted by EC?6.3.5.6, asparaginyl-tRNA synthase (glutamine-hydrolysing), into aspariginyl-tRNAAsn. |
