ATP-dependent NAD(P)H-hydrate dehydratase EC#: 4.2.1.93; ChemWhat Code: 1382378

Product Name ATP-dependent NAD(P)H-hydrate dehydratase
Example Structure Example Structure of ATP-dependent NAD(P)H-hydrate dehydratase EC#: 4.2.1.93
Synonyms (S)-NAD(P)HX dehydratase, ADP-dependent (S)-NAD(P)H-hydrate dehydratase, ADP/ATP-dependent NAD(P)H-hydrate dehydratase, At5g19150, ATP-dependent H4NAD(P)OH dehydratase, ATP-dependent NNRD, BSU38720, Carkd, More, NAD(P)H-hydrate dehydratase, NAD(P)HX dehydratase, NAD(P)X dehydratase, NAXD, NNRD, reduced nicotinamide adenine dinucleotide hydrate dehydratase, YKL151C, YxkO
EC Number 4.2.1.93
CAS Registry Number
Comments Acts equally well on hydrated NADH and hydrated NADPH. NAD(P)H spontaneously hydrates to both the (6S)- and (6R)- isomers, and these are interconverted by EC?5.1.99.6, NAD(P)H-hydrate epimerase, to a 60:40 ratio [4]. Hence EC?4.2.1.93?together with EC?5.1.99.6?can restore the mixture of hydrates into NAD(P)H [3,4]. The enzyme from eukaryotes has no activity with ADP, contrary to the enzyme from bacteria (cf. EC?4.2.1.136, ADP-dependent NAD(P)H-hydrate dehydratase) [4].
Cofactor
History
Reactions (1) Atp + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = Adp + phosphate + nadh. (2) Atp + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = Adp + phosphate + nadph.

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