bile acid CoA-transferase EC#: 2.8.3.25; ChemWhat Code: 1379160
| Product Name | bile acid CoA-transferase |
| Example Structure |  |
| Synonyms | baiF, baiK, bile acid coenzyme A transferase |
| EC Number | 2.8.3.25 |
| CAS Registry Number | |
| Comments | The enzyme, characterized from the gut bacterium?Clostridium scindens, catalyses the last step in bile acid 7¦Á-dehydroxylation, the removal of the CoA moiety from the products. By using a transferase rather than hydrolase, the bacteria conserve the thioester bond energy, saving ATP molecules. The enzyme has a broad substrate specificity and can use multiple acceptors, including allocholate, ursodeoxycholate, and ¦Â-muricholate. Formerly EC?3.1.2.26. |
| Cofactor | |
| History | |
| Reactions | (1) Lithocholoyl-CoA + cholate = lithocholate + choloyl-CoA. (2) Deoxycholoyl-CoA + cholate = deoxycholate + choloyl-CoA. |
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