[butirosin acyl-carrier protein]-L-glutamate ligase EC#: 6.2.1.39; ChemWhat Code: 1383647

Product Name [butirosin acyl-carrier protein]-L-glutamate ligase
Example Structure Example Structure of [butirosin acyl-carrier protein]-L-glutamate ligase EC#: 6.2.1.39
Synonyms BtrJ, [BtrI acyl-carrier protein]L-glutamate ligase
EC Number 6.2.1.39
CAS Registry Number
Comments Catalyses two steps in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family. The enzyme adds one molecule of?L-glutamate to a dedicated acyl-carrier protein, and following decarboxylation of the product by EC?4.1.1.95,?L-glutamyl-[BtrI acyl-carrier protein] decarboxylase, adds a second?L-glutamate molecule. Requires Mg2+?or Mn2+, and activity is enhanced in the presence of Mn2+.
Cofactor Mn2+?or?Mg2+
History
Reactions (1) Atp + L-glutamate + [BtrI acyl-carrier protein] = adp + phosphate + L-glutamyl-[BtrI acyl-carrier protein]. (2) Atp + L-glutamate + 4-amino butanoyl-[BtrI acyl-carrier protein] = Adp + phosphate + 4-(L-gamma-glutamylamino)butanoyl-[BtrI acyl-carrier protein].

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