carboxybiotin protein decarboxylase, MadB, MmdB, Na+ pumping malonate decarboxylase
EC Number
7.2.4.1
CAS Registry Number
Comments
The integral membrane protein MadB from the anaerobic bacterium?Malonomonas rubra?is a component of the multienzyme complex EC?4.1.1.89, biotin-dependent malonate decarboxylase. The free energy of the decarboxylation reaction is used to pump Na+?out of the cell. The enzyme is a member of the Na+-translocating decarboxylase family, other members of which include EC?7.2.4.2?[oxaloacetate decarboxylase (Na+?extruding)] and EC?7.2.4.3?[(S)-methylmalonyl-CoA decarboxylase (sodium-transporting)] [2].