(carboxyethyl)arginine beta-lactam-synthase EC#: 6.3.3.4; ChemWhat Code: 1383807

Product Name (carboxyethyl)arginine beta-lactam-synthase
Example Structure Example Structure of (carboxyethyl)arginine beta-lactam-synthase EC#: 6.3.3.4
Synonyms beta-lactam-forming enzyme, beta-lactam-synthetase, betaLS, bls2, synthetase, beta-lactam
EC Number 6.3.3.4
CAS Registry Number
Comments Forms part of the pathway for the biosythesis of the ¦Â-lactamase inhibitor clavulanate in?Streptomyces clavuligerus. It has been proposed [3] that?L-N2-(2-carboxyethyl)arginine is first converted into an acyl-AMP by reaction with ATP and loss of diphosphate, and that the ¦Â-lactam ring is then formed by the intramolecular attack of the ¦Â-nitrogen on the activated carboxy group.
Cofactor
History
Reactions Atp + L-N(2)-(2-carboxyethyl)arginine = amp + diphosphate + deoxyamidinoproclavaminate.

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