carminomycin 4-O-methyltransferase EC#: 2.1.1.292; ChemWhat Code: 1376566

Product Name carminomycin 4-O-methyltransferase
Example Structure Example Structure of carminomycin 4-O-methyltransferase EC#: 2.1.1.292
Synonyms anthracycline 4-O-methyltransferase, COMT, DauK, DnrK
EC Number 2.1.1.292
CAS Registry Number
Comments The enzymes from the Gram-positive bacteria Streptomyces sp. C5 and Streptomyces peucetius are involved in the biosynthesis of the anthracycline daunorubicin. In vitro the enzyme from Streptomyces sp. C5 also catalyses the 4-O-methylation of 13-dihydrocarminomycin, rhodomycin D and 10-carboxy-13-deoxycarminomycin [3].
Cofactor
History
Reactions S-adenosyl-L-methionine + carminomycin = S-adenosyl-L-homocysteine + daunorubicin.

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