cGMP-dependent protein kinase EC#: 2.7.11.12; ChemWhat Code: 1379013

Product Name cGMP-dependent protein kinase
Example Structure Example Structure of cGMP-dependent protein kinase EC#: 2.7.11.12
Synonyms CGK, CGK 1 alpha, CGK 1 beta, cGK I, cGK II, cGK-I, cGK-II, cGKI, cGKI alpha, cGKI beta, CGKI-alpha, cGKI-beta, cGKIalpha, cGKIbeta, cGKII, cGMP kinase, cGMP-dependent protein kinase, cGMP-dependent protein kinase 1, alpha isozyme, cGMP-dependent protein kinase 1, beta isozyme, cGMP-dependent protein kinase 2, cGMP-dependent protein kinase I, cGMP-dependent protein kinase I alpha, cGMP-dependent protein kinase I gamma, cGMP-dependent protein kinase Ialpha, cGMP-dependent protein kinase Ibeta, cGMP-dependent protein kinase II, cGMP-dependent protein kinase type I, cGMP-dependent protein kinase type II, cGMP-dependent protein kinase, isozyme 1, cGMP-dependent protein kinase, isozyme 2 forms cD5/T2, cGMP-dependent protein kinase-1, cGMP-dependent protein kinase-I, cGMP-protein kinase G, cyclic GMP-dependent kinase, cyclic GMP-dependent kinase I, cyclic GMP-dependent protein kinase, cyclic GMP-dependent protein kinase-1, cyclic guanosine-3′, 5′-monophosphate-dependent protein kinase, cyclic guanosine-3′,5′-monophoshate-dependent protein kinase, cyclic-GMP dependent protein kinase, cylcic GMP protein kinase G, DG1 protein kinase, DG2P1, DG2P2, FOR1, Foraging protein, guanosine 3,5-cyclic monophosphate-dependent protein kinase, guanosine cyclic 3′,5′-phosphate dependent protein kinase, More, PGK II, PKG, PKG I, PKG Ialpha, PKG Ibeta, PKG II, PKG type I, PKG type Ialpha, PKG-1, PKG-I, PKG-Ialpha, PKG2, PKGI, PKGIalpha, PKGIbeta, PKGIgamma, PKGII, PRKG1, protein kinase G, type 1 PKG, type 1alpha PKG, type 2 cGMP-dependent protein kinase, type I beta isozyme of cGMP-dependent protein kinase, type I cGMP-dependent protein kinase, type Ialpha cGMP-dependent protein kinase, type II cGMP dependent protein kinase, Type II cGMP-dependent protein kinase, type II cyclic guanosine monophosphate-dependent protein kinase
EC Number 2.7.11.12
CAS Registry Number
Comments cGMP is required to activate this enzyme. The enzyme occurs as a dimer in higher eukaryotes. The C-terminal region of each polypeptide chain contains the catalytic domain that includes the ATP and protein substrate binding sites. This domain catalyses the phosphorylation by ATP to specific serine or threonine residues in protein substrates [3]. The enzyme also has two allosteric cGMP-binding sites (sites A and B). Binding of cGMP causes a conformational change that is associated with activation of the kinase [4].
Cofactor
History
Reactions Atp + a protein = adp + a phosphoprotein.

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