cholesterol 25-hydroxylase EC#: 1.14.99.38; ChemWhat Code: 1375919
| Product Name | cholesterol 25-hydroxylase |
| Example Structure |  |
| Synonyms | CH25A, CH25H, cholesterol 25-hydroxylase, cholesterol 25-monooxygenase, cholesterol-25-hydroxylase, CYP1A2, CYP27A1, CYP2C9, CYP2D6, CYP3A, Cyp3a11, CYP3A4 |
| EC Number | 1.14.99.38 |
| CAS Registry Number | |
| Comments | Unlike most other sterol hydroxylases, this enzyme is not a cytochrome P450. Instead, it uses diiron cofactors to catalyse the hydroxylation of hydrophobic substrates [1]. The diiron cofactor can be either Fe-O-Fe or Fe-OH-Fe and is bound to the enzyme through interactions with clustered histidine or glutamate residues [4,5]. In cell cultures, this enzyme down-regulates cholesterol synthesis and the processing of sterol regulatory element binding proteins (SREBPs). |
| Cofactor | Fe cation |
| History | |
| Reactions | Cholesterol + AH(2) + O(2) = 25-hydroxycholesterol + A + H(2)O. |
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