cobyrinate a,c-diamide synthase EC#: 6.3.5.11; ChemWhat Code: 1383870
| Product Name | cobyrinate a,c-diamide synthase |
| Example Structure |  |
| Synonyms | CbiA, CobB |
| EC Number | 6.3.5.11 |
| CAS Registry Number | |
| Comments | This enzyme is the first glutamine amidotransferase that participates in the anaerobic (early cobalt insertion) biosynthetic pathway of adenosylcobalamin, and catalyses the ATP-dependent synthesis of cobyrinate?a,c-diamide from cobyrinate using either?L-glutamine or ammonia as the nitrogen source. It is proposed that the enzyme first catalyses the amidation of the?c-carboxylate, and then the intermediate is released into solution and binds to the same catalytic site for the amidation of the?a-carboxylate. The?Km?for ammonia is substantially higher than that for?L-glutamine. |
| Cofactor | |
| History | |
| Reactions | 2 Atp + cobyrinate + 2 L-glutamine + 2 H(2)O = 2 adp + 2 phosphate + cobyrinate a,c-diamide + 2 L-glutamate. |
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