cypemycin N-terminal methyltransferase EC#: 2.1.1.301; ChemWhat Code: 1376581

Product Name cypemycin N-terminal methyltransferase
Example Structure Example Structure of cypemycin N-terminal methyltransferase EC#: 2.1.1.301
Synonyms alpha-N-methyltransferase, CypM, S-adenosyl methionine-dependent methyltransferase
EC Number 2.1.1.301
CAS Registry Number
Comments The enzyme, isolated from the bacterium Streptomyces sp. OH-4156, can methylate a variety of oligopeptides, cyclic peptides such as nisin and haloduracin, and the ¦Å-amino group of lysine [2]. Cypemycin is a peptide antibiotic, a member of the linaridins, a class of posttranslationally modified ribosomally synthesized peptides.
Cofactor
History
Reactions 2 S-adenosyl-L-methionine + N-terminal L-alanine-[cypemycin] = 2 S-adenosyl-L-homocysteine + N-terminal N,N-dimethyl-L-alanine- [cypemycin].

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