D-2-hydroxyacid dehydrogenase (NADP+) EC#: 1.1.1.272; ChemWhat Code: 1373366
| Product Name | D-2-hydroxyacid dehydrogenase (NADP+) |
| Example Structure |  |
| Synonyms | CbiH60, Precorrin-3 methylase |
| EC Number | 1.1.1.272 |
| CAS Registry Number | |
| Comments | This enzyme, characterized from the halophilic archaeon Haloferax mediterranei and the mold Aspergillus oryzae, catalyses a reversible stereospecific reduction of 2-oxocarboxylic acids into the corresponding D-2-hydroxycarboxylic acids. The enzyme prefers substrates with a main chain of 5 carbons (such as 4-methyl-2-oxopentanoate) to those with a shorter chain, and can use NADH with much lower efficiency. cf. EC 1.1.1.345, (D)-2-hydroxyacid dehydrogenase (NAD+). |
| Cofactor | |
| History | |
| Reactions | An (R)-2-hydroxycarboxylate + NADP(+) = a 2-oxocarboxylate + Nadph. |
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