D-alanine-D-serine ligase EC#: 6.3.2.35; ChemWhat Code: 1383773

Product Name D-alanine-D-serine ligase
Example Structure Example Structure of D-alanine-D-serine ligase EC#: 6.3.2.35
Synonyms D-alanine:D-serine ligase, VanC2, vanC2/3, VanE, VanG, vanGCar, VanL
EC Number 6.3.2.35
CAS Registry Number
Comments The product of this enzyme,?D-alanyl-D-serine, can be incorporated into the peptidoglycan pentapeptide instead of the usual?D-alanyl-D-alanine dipeptide, which is formed by EC?6.3.2.4,?D-alanine¡ªD-alanine ligase. The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria.
Cofactor
History
Reactions D-alanine + D-serine + Atp = D-alanyl-D-serine + adp + phosphate.

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