D-aspartate ligase EC#: 6.3.1.12; ChemWhat Code: 1383686
| Product Name | D-aspartate ligase |
| Example Structure |  |
| Synonyms | aslA, Aslfm, D-aspartic acid-activating enzyme, UDP-MurNAc-pentapeptide:D-aspartate ligase |
| EC Number | 6.3.1.12 |
| CAS Registry Number | |
| Comments | This enzyme forms part of the peptidoglycan assembly pathway of Gram-positive bacteria grown in medium containing?D-Asp. Normally, the side chains the acylate the 6-amino group of the?L-lysine residue contain?L-Ala-L-Ala but these amino acids are replaced by?D-Asp when?D-Asp is included in the medium. Hybrid chains containing?L-Ala-D-Asp,?L-Ala-L-Ala-D-Asp or?D-Asp-L-Ala are not formed [4]. The enzyme belongs in the ATP-grasp protein superfamily [3,4]. The enzyme is highly specific for?D-aspartate, as?L-aspartate,?D-glutamate,?D-alanine,?D-iso-asparagine and?D-malic acid are not substrates [4]. In?Enterococcus faecium, the substrate?D-aspartate is produced by EC?5.1.1.13, aspartate racemase [4]. |
| Cofactor | |
| History | |
| Reactions | Atp + D-aspartate + (beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L- Lys-D-Ala-D-Ala))(n) = (beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu- 6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala))(n) + Adp + phosphate. |
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