D-proline reductase EC#: 1.21.4.1; ChemWhat Code: 1376088
| Product Name | D-proline reductase |
| Example Structure |  |
| Synonyms | 5-aminopentanoate:lipoate oxidoreductase (cyclizing), D-proline reductase, D-proline reductase (dithiol), EC 1.4.1.6, EC 1.4.4.1, lipoate-linked proline reductase, PrdB |
| EC Number | 1.21.4.1 |
| CAS Registry Number | 37255-43-9 |
| Comments | A pyruvoyl- and L-selenocysteine-containing enzyme found in a number of Clostridial species. The pyruvoyl group, located on the PrdA subunit, binds the substrate, while the selenocysteine residue, located on the PrdB subunit, attacks the ¦Á-C-atom of D-proline, leading to a reductive cleavage of the C-N-bond of the pyrrolidine ring and formation of a selenoether. The selenoether is cleaved by a cysteine residue of PrdB, resulting in a mixed selenide-sulfide bridge, which is restored to its reduced state by another selenocysteine protein, PrdC. 5-aminopentanoate is released from PrdA by hydrolysis, regenerating the pyruvoyl moiety. The resulting mixed selenide-sulfide bridge in PrdC is reduced by NADH. Formerly EC 1.4.1.6 and EC 1.4.4.1. |
| Cofactor | |
| History | |
| Reactions | 5-aminopentanoate + lipoate = D-proline + dihydrolipoate. |
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