diguanylate cyclase EC#: 2.7.7.65; ChemWhat Code: 1378862
| Product Name | diguanylate cyclase |
| Example Structure |  |
| Synonyms | AdrA, ALL2874, atu1060, atu1297, BifA, CdgA, CdgB, CelR, Chp8, cyclic dimeric GMP [c-di-GMP] B, Dcsbis, DGC, Dgc1, DgcA, DgcP, DgcZ, diguanylate cyclase, direct oxygen sensing cyclase, DosC, DosD, EcDosC, etDGC, GcbA, gcbB, gcbC, GG(D/E)EF diguanylate cyclase, HemDGC, heme-containing diguanylate cyclase, MifA, MifB, ML1419, PA2771, PA4367, Pfl01_1058, Pfl01_1789, Pfl01_4666, PGN_1932, PleD, Q9HW69 {UniProt}, RoeA, Rrp1, sadC, SesA, SwDGC, Swoo_2750, tDGC, thermophilic diguanylate cyclase domain protein, Tlr0924, TM_1788, VC2370, VCA0965, WspR, XAC0610, XOO3988, YddV, YdeH, YfiN, YhcK |
| EC Number | 2.7.7.65 |
| CAS Registry Number | 146316-82-7 |
| Comments | A GGDEF-domain-containing protein that requires Mg2+ or Mn2+ for activity. The enzyme can be activated by BeF3, a phosphoryl mimic, which results in dimerization [4]. Dimerization is required but is not sufficient for diguanylate-cyclase activity [4]. Cyclic di-3′,5′-guanylate is an intracellular signalling molecule that controls motility and adhesion in bacterial cells. It was first identified as having a positive allosteric effect on EC?2.4.1.12, cellulose synthase (UDP-forming) [1]. |
| Cofactor | Mn2+; Mg2+ |
| History | |
| Reactions | 2 Gtp = 2 diphosphate + cyclic di-3′,5′-guanylate. |
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