diphthine methyl ester synthase EC#: 2.1.1.314; ChemWhat Code: 1376596

Product Name diphthine methyl ester synthase
Example Structure Example Structure of diphthine methyl ester synthase EC#: 2.1.1.314
Synonyms diphthine methyltransferase, Dph5, S-adenosyl-L-methionine:elongation factor 2 methyltransferase
EC Number 2.1.1.314
CAS Registry Number
Comments This eukaryotic enzyme is part of the biosynthetic pathway of diphthamide. Different from the archaeal enzyme, which performs only 3 methylations, producing diphthine (cf. EC 2.1.1.98). The relevant histidine of elongation factor 2 is His715 in mammals and His699 in yeast.
Cofactor
History
Reactions 4 S-adenosyl-L-methionine + 2-((3S)-3-carboxy-3-aminopropyl)-L-histidine- [translation elongation factor 2] = 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2].

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