E1 ubiquitin-activating enzyme EC#: 6.2.1.45; ChemWhat Code: 1383653

Product Name E1 ubiquitin-activating enzyme
Example Structure Example Structure of E1 ubiquitin-activating enzyme EC#: 6.2.1.45
Synonyms AtUBA1, AtUBA2, E1, E1 ubiquitin-activating enzyme, HsUba1a, NEDD8-activating enzyme E1 catalytic subunit, non-canonical ubiquitin activating enzyme, SUMO E1, UB activating enzyme, Ub E1 activating enzyme, Ub-activating enzyme, Ub-activating ligase, Uba1, Uba1a, UBA1p, UBA2, Uba3, UBA5, Uba6, UBE1, UBE1DC1, UBE1DC1A, UBE1DC1B, UBE1L2, ubiquitin activating enzyme, ubiquitin activating enzyme 2, ubiquitin activating enzyme E1, ubiquitin E1, ubiquitin protein ligase E1, Ubiquitin-activating enzyme, ubiquitin-activating enzyme (E1), ubiquitin-activating enzyme 1, ubiquitin-activating enzyme 5, ubiquitin-activating enzyme 6, ubiquitin-activating enzyme E1, ubiquitin-activating enzyme E1 domain-containing protein 1, ubiquitin-activating enzyme E1-domain containing 1, ubiquitin-activating enzyme, UBE1, ubiquitin-conjugating enzyme, ubiquitin-like modifier-activating enzyme 1, ubiquitin-like modifier-activating enzyme 5, ubiquitin-like modifier-activating enzyme 6
EC Number 6.2.1.45
CAS Registry Number
Comments Catalyses the ATP-dependent activation of ubiquitin through the formation of a thioester bond between the C-terminal glycine of ubiquitin and the sulfhydryl side group of a cysteine residue in the E1 protein. The two-step reaction consists of the ATP-dependent formation of an?E1-ubiquitin adenylate intermediate in which the C-terminal glycine of ubiquitin is bound to AMP via an acyl-phosphate linkage, then followed by the conversion to an?E1-ubiquitin thioester bond via the cysteine residue on E1 in the second step. Formerly EC?6.3.2.19?and EC?6.3.2.21.
Cofactor
History
Reactions Atp + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = amp + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.

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