formate-phosphoribosylaminoimidazolecarboxamide ligase EC#: 6.3.4.23; ChemWhat Code: 1383851

Product Name formate-phosphoribosylaminoimidazolecarboxamide ligase
Example Structure Example Structure of formate-phosphoribosylaminoimidazolecarboxamide ligase EC#: 6.3.4.23
Synonyms 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase, 5-formaminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5′-monophosphate synthetase, PurP
EC Number 6.3.4.23
CAS Registry Number
Comments This archaeal enzyme, characterized from the methanogen?Methanocaldococcus jannaschii, catalyses a step in the synthesis of purine nucleotides. It differs from the orthologous bacterial/eukaryotic enzymes, which utilize 10-formyltetrahydrofolate rather than formate and ATP.?cf. EC?2.1.2.3, phosphoribosylaminoimidazolecarboxamide formyltransferase.
Cofactor
History
Reactions Atp + formate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = Adp + phosphate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide.

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