formate-tetrahydrofolate ligase EC#: 6.3.4.3; ChemWhat Code: 1383819
| Product Name | formate-tetrahydrofolate ligase |
| Example Structure |  |
| Synonyms | 10-formyl-THF synthetase, 10-Formyltetrahydrofolate synthetase, 10-formylTHF synthetase, ADE3, C(1)-tetrahydrofolate synthase, C1 synthase, C1-tetrahydrofolate synthase, C1-tetrahydrofolate synthetase, C1-THF synthase, C1-THFS, CpeFhs, DCS, dehydrogenasse-cyclohydrolase-synthetase, FHS, formate-tetrahydrofolate ligase, formate:tetrahydrofolate ligase (ADP-forming), formyl tetrahydrofolate synthetase, Formyl-THF synthetase, Formyltetrahydrofolate synthetase, ftfL, FTHFS, FTL, methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase, methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase enzyme, MIS1, MTHFD, MTHFD1, MTHFD1L, N10-formyltetrahydrofolate synthetase, Synthetase, formyl tetrahydrofolate, Tetrahydrofolate formylase, Tetrahydrofolic formylase, THF synthase, THFS |
| EC Number | 6.3.4.3 |
| CAS Registry Number | 9023-66-9 |
| Comments | In eukaryotes occurs as a trifunctional enzyme also having methylenetetrahydrofolate dehydrogenase (EC?1.5.1.5) and methenyltetrahydrofolate cyclohydrolase (EC?3.5.4.9) activity. |
| Cofactor | |
| History | |
| Reactions | Atp + formate + tetrahydrofolate = adp + phosphate + 10-formyltetrahydrofolate. |
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