| Synonyms |
ATCV-1GMD, bceN, Dm-gmd, GDP-alpha-D-mannose 4,6-dehydratase, GDP-D-mannose 4,6-dehydratase, GDP-D-mannose 4-oxido-6-reductase, GDP-D-mannose dehydratase, GDP-D-mannose-4,6-dehydratase, GDP-mannose 4, 6-dehydratase, GDP-mannose 4,6 dehydratase, GDP-mannose 4,6-dehydratase, GDP-mannose dehydratase, GDP-mannose dehydrogenase, GDP-mannose-4,6-dehydratase, GMD, GMDS, guanosine 5′-diphosphate-D-mannose 4,6-dehydratase, Guanosine 5′-diphosphate-D-mannose oxidoreductase, Guanosine diphosphomannose 4,6-dehydratase, Guanosine diphosphomannose oxidoreductase, L-GMD, M-GMD, MUR1, ORF13.7, PBCV-1 GMD, S-GMD |
| Comments |
The bacterial enzyme requires bound NAD+. This enzyme forms the first step in the biosynthesis of GDP-¦Á-D-rhamnose and GDP-¦Á-L-fucose. In?Aneurinibacillus thermoaerophilus?L420-91T, this enzyme acts as a bifunctional enzyme, catalysing the above reaction as well as the reaction catalysed by EC?1.1.1.281, GDP-4-dehydro-6-deoxy-D-mannose reductase [5]. Belongs to the short-chain dehydrogenase/reductase enzyme family, having homologous structures and a conserved catalytic triad of Lys, Tyr and Ser/Thr residues [6]. |
