GDP polyribonucleotidyltransferase EC#: 2.7.7.88; ChemWhat Code: 1378899
Product Name
GDP polyribonucleotidyltransferase
Example Structure
Synonyms
GDP polyribonucleotidyltransferase, L protein, L-pRNA complex, PRNTase, RNA-directed RNA polymerase L, RNA:GDP polyribonucleotidyltransferase
EC Number
2.7.7.88
CAS Registry Number
Comments
The enzyme from rhabdoviruses transfers 5′-monophosphorylated (p-)mRNA from 5′-triphosphorylated (ppp-)mRNA to GDP to form 5′-capped mRNA (GpppmRNA) in a viral mRNA-start sequence-dependent manner. The (p-)mRNA transfer reaction proceeds through a covalent enzyme-pmRNA intermediate.
Cofactor
History
Reactions
5′-triphospho-mRNA + Gdp = diphosphate + guanosine 5′-triphospho-mRNA.
