glutathionylspermidine synthase EC#: 6.3.1.8; ChemWhat Code: 1383677
| Product Name | glutathionylspermidine synthase |
| Example Structure |  |
| Synonyms | bifunctional glutathionylspermidine synthetase/amidase, Gen Bank AE000381-derived protein GI 1789361, GenBank U66520-derived protein GI 1813514, Glutathione:spermidine ligase (ADP-forming), Glutathione:spermidine ligase [ADP-forming], glutathionylspermidine synthetase, Glutathionylspermidine synthetase (Crithidia fasciculata strain HS6 gene Cf-GSS), Glutathionylspermidine synthetase (Crithidia fasciculata), Glutathionylspermidine synthetase/amidase, Gsp synthetase, GspS, GspSA, LiGSPS, Protein (Escherichia coli strain K12-MG1655 gene gsp), Synthetase, glutathionylspermidine, Synthetase, glutathionylspermidine (Crithidia fasciculata fragment), Synthetase, glutathionylspermidine (Crithidia fasciculata strain HS6 gene Cf-GSS), Synthetase, glutathionylspermidine (Crithidia fasciculata), Synthetase, glutathionylspermidine (Escherichia coli clone pJBM1 gene gsp), TryS |
| EC Number | 6.3.1.8 |
| CAS Registry Number | 9077/9/2 |
| Comments | Requires magnesium ions. Involved in the synthesis of trypanothione in trypanosomatids. The enzyme from?Escherichia coli?is bifunctional and also catalyses the glutathionylspermidine amidase (EC?3.5.1.78) reaction, resulting in a net hydrolysis of ATP. |
| Cofactor | Mg2+ |
| History | |
| Reactions | Glutathione + spermidine + Atp = glutathionylspermidine + adp + phosphate. |
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