glycine N-methyltransferase EC#: 2.1.1.20; ChemWhat Code: 1376158

Product Name glycine N-methyltransferase
Example Structure Example Structure of glycine N-methyltransferase EC#: 2.1.1.20
Synonyms 4S polycyclic aromatic hydrocarbon binding protein, glycine methyltransferase, glycine N-methyltransferase, glycine-N methyltransferase, GNMT, Gnmt gene product, methyltransferase, glycine, S-adenosyl-L-methionine:glycine methyltransferase
EC Number 2.1.1.20
CAS Registry Number 37228-72-1
Comments This enzyme is thought to play an important role in the regulation of methyl group metabolism in the liver and pancreas by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine. It is inhibited by 5-methyltetrahydrofolate pentaglutamate [4]. Sarcosine, which has no physiological role, is converted back into glycine by the action of EC 1.5.8.3, sarcosine dehydrogenase.
Cofactor
History
Reactions S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine.

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