| Synonyms |
(glycosyl)phosphatidylinositol-specific phospholipase C, EC 3.1.4.47, GDE3, glycan-phosphatidylinositol-specific phospholipase C, glycosyl inositol phospholipid anchor-hydrolyzing enzyme, glycosylphosphatidylinositol phospholipase C, glycosylphosphatidylinositol-phospholipase C, glycosylphosphatidylinositol-specific phospholipase C, glycosylphosphatidylinositol-specific phospholipase D, GPI-PC, GPI-phosphatidylinositol-phospholipase C, GPI-phospholipase C, GPI-phospholipase C polypeptide, GPI-PLC, GPI-PLC enzyme, GPI-PLCp, GPI-PLD, GPI-specific phospholipase C, phospholipase C, glycosylphosphatidylinositol, variant-surface-glycoprotein phospholipase C, variant-surface-glycoprotein-1,2-didecanoyl-sn-phosphatidylinositol inositolphosphohydrolase, VSG-lipase |
| Comments |
This enzyme is also active when O-4 of the glucosamine is substituted by carrying the oligosaccharide that can link a protein to the structure. It therefore cleaves proteins from the lipid part of the glycosylphostphatidylinositol (GPI) anchors. In some cases, the long-chain acyl group at the?sn-1 position of glycerol is replaced by an alkyl or alk-1-enyl group. In other cases, the diacylglycerol is replaced by ceramide. The only characterized enzyme with this specificity is from?Trypanosoma brucei, where the acyl groups are myristoyl, but the function of the trypanosome enzyme is unknown. Substitution on O-2 of the inositol blocks action of this enzyme. It is not identical with EC?3.1.4.50, glycosylphosphatidylinositol phospholipase D. |
