GMP synthase (glutamine-hydrolysing) EC#: 6.3.5.2; ChemWhat Code: 1383856
| Product Name | GMP synthase (glutamine-hydrolysing) |
| Example Structure |  |
| Synonyms | cgsA, di-GMP synthase A, GATase, Glutamine amidotransferase, GMP synthase, GMP synthase [glutamine-hydrolyzing] subunit B, GMP synthetase, GMP synthetase (glutamine hydrolysing), GMPS, GUA, GuaA, Guanine monophosphate synthetase, Guanosine 5′-monophosphate synthetase, Guanosine 5-monophosphate synthetase, guanosine monophosphate synthetase, Guanosine monophosphate synthetase (glutamine-hydrolyzing), Guanylate synthetase, Guanylate synthetase (glutamine-hydrolyzing), More, PD0279, PH1346, Synthetase, guanylate, two-subunit-type GMP synthetase, Xanthosine 5′-phosphate amidotransferase, Xanthosine 5-monophosphate aminase, Xanthosine-5′-phosphate-ammonia ligase, Xanthosine-5′-phosphate:ammonia ligase (AMP-forming), XMP aminase |
| EC Number | 6.3.5.2 |
| CAS Registry Number | 37318-71-1 |
| Comments | Involved in the?de novo?biosynthesis of guanosine nucleotides. An N-terminal glutaminase domain binds?L-glutamine and generates ammonia, which is transferred by a substrate-protective tunnel to the ATP-pyrophosphatase domain. The enzyme can catalyse the second reaction alone in the presence of ammonia. Formerly EC?6.3.4.1. |
| Cofactor | |
| History | |
| Reactions | Atp + xmp + L-glutamine + H(2)O = amp + diphosphate + gmp + L-glutamate. |
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