[histone H3]-lysine36 N-dimethyltransferase EC#: 2.1.1.357; ChemWhat Code: 1376643

Product Name [histone H3]-lysine36 N-dimethyltransferase
Example Structure Example Structure of [histone H3]-lysine36 N-dimethyltransferase EC#: 2.1.1.357
Synonyms Ash1L, KMT3B, KMT3C, NSD2, SETMAR, Whsc1
EC Number 2.1.1.357
CAS Registry Number
Comments This entry describes a group of metazoan enzymes that catalyse two successive methylations of lysine36 of histone H3 (H3K36), forming mono- and dimethylated forms. These modifications influence the binding of chromatin-associated proteins. The product can be further methylated to the trimethyl form by EC 2.1.1.358, [histone H3]-dimethyl-L-lysine36 N-methyltransferase. The yeast SET2 enzyme can catalyse all three methylations (see EC 2.1.1.359, [histone H3]-lysine36 N-trimethyltransferase).
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