[histone H3]-lysine4 N-trimethyltransferase EC#: 2.1.1.354; ChemWhat Code: 1376640

Product Name [histone H3]-lysine4 N-trimethyltransferase
Example Structure Example Structure of [histone H3]-lysine4 N-trimethyltransferase EC#: 2.1.1.354
Synonyms Arabidopsis homolog of trithorax-1, Ash1L, Ash2L, ASHH1/SDG26, ASHH2, ATX1, chromatin histone H3-lysine 4 methyltransferase, COMPASS, COMPASS histone methyltransferase, DOT1L, Dpy-30, dSet1, H3-K4 HMT, H3K4 HMT, H3K4 HMTase, H3K4 methyltransferase, H3K4 trimethyltransferase, H3K4MT, histone 3 lysine 4 methyltransferase, histone H3 lysine 4 methyltransferase, histone H3 lysine 4 methyltransferase activity, histone H3 lysine 4 trimethyltransferase, histone H3 methyltransferase, histone H3-lysine-4 methyltransferase, histone H3K4 methyltransferase, histone H3K4 methyltransferase complex, histone lysine methyltransferase, histone lysine methyltransferase SET7/9, histone methyltransferase complex, HKMT, HMT, HMTase, Hst1, hybrid sterility protein 1, KMT2A, KMT2B, KMT2C, KMT2D, KMT2E, KMT2F, KMT2G, KMT2H, KMT3C, KMT3E, KMT7, mixed lineage leukemia protein, MLL, MLL1, MLL2, MLL3, MLL3/MLL4, MLL4, MLL5, PA1, PKMT, PRDM7, Prdm9, protein lysine methyltransferases, RbBP5, SET domain group 26, SET-domain protein lysine methyltransferase, SET1, set1 histone H3-Lys4 methyltransferase complex, SET1C, Set1p, SET7, SET7/9, Setd1A, Setd1B, SetD7, SMYD1, Smyd2, Smyd3
EC Number 2.1.1.354
CAS Registry Number
Comments This entry describes several enzymes that successively methylate the L-lysine4 residue of histone H3 (H3K4), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. In most cases the trimethylation of this position is associated with gene activation. Unlike the other enzymes, KMT7 catalyses only monomethylation. Formerly EC 2.1.1.43.
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