[histone H3]-lysine79 N-trimethyltransferase EC#: 2.1.1.360; ChemWhat Code: 1376646
| Product Name | [histone H3]-lysine79 N-trimethyltransferase |
| Example Structure | ![Example Structure of [histone H3]-lysine79 N-trimethyltransferase EC#: 2.1.1.360](/wp-content/uploads/enzyme-structure/2.1.1.360.jpg) |
| Synonyms | Dot1, DOT1B, DOT1L, grappa, histone H3 lysine-79 methyltransferase, histone H3K79 methyltransferase, histone lysine methyltransferase, histone methyltransferase, HMT, KMT4, mDot1a, murine disruptor of telomeric silencing alternative splice variant a, Rad9 |
| EC Number | 2.1.1.360 |
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| Comments | The enzyme successively methylates the L-lysine79 residue of histone H3 (H3K79), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. This is the only known methylation event of a lysine residue within the core region of a histone, as all other such modifications occur at the tail. Formerly EC 2.1.1.43. |
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